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1

First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Hérault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

2

The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Dr. Constant A. A. van Boeckel, Dr. Maurice Petitou

Journal:

Angewandte Chemie International Edition

Year:

1993

Language:

english

File:

PDF, 2.54 MB

english, 1993

3

Conformation of the pentasaccharide corresponding to the binding site of heparin for antithrombin III

Massimo Ragazzi, Dino R. Ferro, Bruno Perly, Pierre Sinaÿ, Maurice Petitou, Jean Choay

Journal:

Carbohydrate Research

Year:

1990

Language:

english

File:

PDF, 1.10 MB

english, 1990

4

A new, highly potent, heparin-like pentasaccharide fragment containing a glucose residue instead of a glucosamine

M. Petitou, G. Jaurand, M. Derrien, P. Duchaussoy, J. Choay

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 298 KB

english, 1991

5

SR 90107A/Org 31540, a Novel Anti-Factor Xa Antithrombotic Agent

J. M. Herbert, M. Petitou, J. C. Lormeau, R. Cariou, J. Necciari, H. N. Magnani, P. Zandberg, R. G. M. van Amsterdam, C. A. A. van Boeckel, D. G. Meuleman

Journal:

Cardiovascular Therapeutics

Year:

1997

Language:

english

File:

PDF, 1.20 MB

english, 1997

6

Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy

P. SAVI, J. P. HERAULT, P. DUCHAUSSOY, L. MILLET, P. SCHAEFFER, M. PETITOU, F. BONO, J. M. HERBERT

Journal:

Journal of Thrombosis and Haemostasis

Year:

2008

Language:

english

File:

PDF, 393 KB

english, 2008

7

10.1038/18877

Herbert, Jean-Marc, Petitou, Maurice, Hérault, Jean-Pascal, Bernat, André, Driguez, Pierre-Alexandre, Duchaussoy, Philippe, Lormeau, Jean-Claude

Journal:

Year:

1999

Language:

english

File:

PDF, 420 KB

english, 1999

8

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

Roy, Sucharita, El Hadri, Ahmed, Richard, Sebastien, Denis, Fanny, Holte, Kimberly, Duffner, Jay, Yu, Fei, Galcheva-Gargova, Zoya, Capila, Ishan, Schultes, Birgit, Petitou, Maurice, Kaundinya, Ganesh

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.06 MB

english, 2014

9

Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators

Z. C. Han, S. Bellucci, Z. X. Shen, J. P. Maffrand, M. Pascal, M. Petitou, J. Lormeau, J. P. Caen

Journal:

Journal of Cellular Physiology

Year:

1996

Language:

english

File:

PDF, 740 KB

english, 1996

10

Die ersten synthetischen Kohlenhydrate mit den vollständigen antikoagulierenden Eigenschaften von Heparin

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Hérault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 215 KB

german, 1998

11

Further Evidence for the Critical Role of a Non-Chair Conformation of L-Iduronic Acid in the Activation of Antithrombin

José Kovensky, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Sizun, Jean-Pascal Hérault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 174 KB

english, 2002

12

Titelbild

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Hérault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

Angewandte Chemie

Year:

2001

Language:

german

File:

PDF, 25 KB

german, 2001

13

Synthese konformativ fixierter Kohlenhydrate: Eine Skew-Bootkonformation der L-Iduronsäure in Heparin bestimmt dessen antithrombotische Aktivität

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Hérault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

Angewandte Chemie

Year:

2001

Language:

german

File:

PDF, 111 KB

german, 2001

14

Experimental Proof for the Structure of a Thrombin-Inhibiting Heparin Molecule

Maurice Petitou, Anne Imberty, Philippe Duchaussoy, Pierre-Alexandre Driguez, Marie-Line Ceccato, Françoise Gourvenec, Philippe Sizun, Jean-Pascal Hérault, Serge Pérez, Jean-Marc Herbert

Journal:

Chemistry - A European Journal

Year:

2001

Language:

english

File:

PDF, 347 KB

english, 2001

15

Synthesis of Conformationally Locked l-Iduronic Acid Derivatives: Direct Evidence for a Critical Role of the Skew-Boat 2S0 Conformer in the Activation of Antithrombin by Heparin

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Herault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

Chemistry - A European Journal

Year:

2001

Language:

english

File:

PDF, 298 KB

english, 2001

16

Cover Picture

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Hérault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 25 KB

english, 2001

17

Synthesis of Conformationally Locked Carbohydrates: A Skew-Boat Conformation of L-Iduronic Acid Governs the Antithrombotic Activity of Heparin

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Hérault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinaÿ

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

18

Die charakteristische AT-III-Bindungsregion in Heparin: eine Leitstruktur für neue synthetische Antithrombotica

Dr. Constant A. A. van Boeckel, Dr. Maurice Petitou

Journal:

Angewandte Chemie

Year:

1993

Language:

german

File:

PDF, 2.70 MB

german, 1993

19

Ein synthetisches Antithrombin III bindendes Pentasaccharid ist jetzt ein Wirkstoff! Was kommt danach?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Angewandte Chemie

Year:

2004

Language:

german

File:

PDF, 643 KB

german, 2004

20

A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 628 KB

english, 2004

21

Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids

Nicolas Sapay, Éric Cabannes, Maurice Petitou, Anne Imberty

Journal:

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

22

ChemInform Abstract: Synthesis and Biological Activity of a New Anti-Factor Xa Pentasaccharide with a C-Interglycosidic Bond.

A. HELMBOLDT, M. PETITOU, J.-M. MALLET, J.-P. HERAULT, J.-C. LORMEAU, P. A. DRIGUEZ, J.-M. HERBERT, P. SINAY

Journal:

Year:

1997

File:

PDF, 27 KB

1997

23

ChemInform Abstract: A Synthetic Heparin/Heparan Sulfate-Like Decasaccharide Releases Lipase Activity in vivo. Chemical Synthesis and Biological Activity.

M. PETITOU, P. DUCHAUSSOY, A. BERNAT, P. HOFFMANN, J. M. HERBERT

Journal:

Year:

1997

File:

PDF, 25 KB

1997

24

ChemInform Abstract: Synthesis of a C-Disaccharide Glycosyl Donor as a Key Building Block for the Preparation of New Biologically Active Heparin Pentasaccharide Mimetics.

A. HELMBOLDT, J.-M. MALLET, M. PETITOU, P. SINAY

Journal:

Year:

1998

File:

PDF, 35 KB

1998

25

ChemInform Abstract: First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin.

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Herault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Year:

1999

File:

PDF, 26 KB

1999

26

ChemInform Abstract: Synthetic Oligosaccharides Having Various Functional Domains: Potent and Potentially Safe Heparin Mimetics.

Maurice Petitou, Pierre-Alexandre Driguez, Philippe Duchaussoy, Jean-Pascal Herault, Jean-Claude Lormeau, Jean-Marc Herbert

Journal:

Year:

1999

File:

PDF, 25 KB

1999

27

ChemInform Abstract: New Synthetic Heparin Mimetics Able to Inhibit Thrombin and Factor Xa.

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Jean-P. Herault, Jean-C. Lormeau, Jean-M. Herbert

Journal:

Year:

1999

File:

PDF, 24 KB

1999

28

ChemInform Abstract: New Antithrombotic Oligosaccharides

M. Petitou, J. P. Herault, A. Bernat, P. A. Driguez, Ph. Duchaussoy, J. C. Lormeau, J. M. Herbert

Journal:

Year:

1999

File:

PDF, 24 KB

1999

29

ChemInform Abstract: Synthetic Carbohydrate Derivatives as Low Sulfated Heparin Mimetics.

Pierre-A. Driguez, Isidore Lederman, Jean-M. Strassel, Jean-M. Herbert, Maurice Petitou

Journal:

Year:

2000

File:

PDF, 25 KB

2000

30

ChemInform Abstract: Synthesis of Conformationally Locked L-Iduronic Acid Derivatives. Direct Evidence for a Critical Role of the Skew-Boat 2S0 Conformer in the Activation of Antithrombin by Heparin.

Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy, Philippe Sizun, Jean-Pascal Herault, Jean-Marc Herbert, Maurice Petitou, Pierre Sinay

Journal:

Year:

2002

File:

PDF, 27 KB

2002

31

A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Year:

2004

File:

PDF, 52 KB

2004

32

Heparin-derived oligosaccharides: Affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells

Tereza Bârzu, Jean-Claude Lormeau, Maurice Petitou, Susan Michelson, Jean Choay

Journal:

Journal of Cellular Physiology

Year:

1989

Language:

english

File:

PDF, 1.12 MB

english, 1989

33

Selective excitation techniques in 13C NMR. II—new sequences for fast heteronuclear correlation

P. Berthault, B. Perly, M. Petitou

Journal:

Magnetic Resonance in Chemistry

Year:

1990

Language:

english

File:

PDF, 565 KB

english, 1990

34

A simplified procedure for organic phosphorus determination from phospholipids

Maurice Petitou, Françoise Tuy, Claude Rosenfeld

Journal:

Analytical Biochemistry

Year:

1978

Language:

english

File:

PDF, 206 KB

english, 1978

35

Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III

Pierre Sinaÿ, Jean-Claude Jacquinet, Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, Jean Choay, Giangiacomo Torri

Journal:

Carbohydrate Research

Year:

1984

Language:

english

File:

PDF, 254 KB

english, 1984

36

Synthesis of heparin fragments. A chemical synthesis of the trisaccharide O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(2-O-sulfo-α-l-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-d-glucopyranose heptasodium salt

Jean-Claude Jacquinet, Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, Jean Choay, Giangiacomo Torri, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1984

Language:

english

File:

PDF, 1.82 MB

english, 1984

37

Conformation of the pentasaccharide corresponding to the binding site of heparin to Antithrombin-III

Massimo Ragazzi, Dino R. Ferro, Bruno Perly, Giangiacomo Torri, Benito Casu, Pierre Sinaÿ, Maurice Petitou, Jean Choay

Journal:

Carbohydrate Research

Year:

1987

Language:

english

File:

PDF, 259 KB

english, 1987

38

Binding of heparin to antithrombin III: A chemical proof of the critical role played by a 3-sulfated 2-amino-2-deoxy-d-glucose residue

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, Jean Choay, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1988

Language:

english

File:

PDF, 747 KB

english, 1988

39

Synthesis of disaccharide fragments of dermatan sulfate

Alberto Marra, Xia Dong, Maurice Petitou, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1989

Language:

english

File:

PDF, 1.03 MB

english, 1989

40

Selectively O-acylated glycosaminoglycan derivatives

Maurice Petitou, Catherine Coudert, Michel Level, Jean-Claude Lormeau, Martin Zuber, Catherine Simenel, Jean-Paul Fournier, Jean Choay

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 1.12 MB

english, 1992

41

l-Iduronic acid derivatives as glycosyl donors

Christine Tabeur, Françoise Machetto, Jean-Maurice Mallet, Philippe Duchaussoy, Maurice Petitou, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1996

Language:

english

File:

PDF, 2.73 MB

english, 1996

42

Binding of heparan sulfate to fibroblast growth factor-2 total synthesis of a putative pentasaccharide binding site

José Kovensky, Philippe Duchaussoy, Maurice Petitou, Pierre Sinaÿ

Journal:

Tetrahedron: Asymmetry

Year:

1996

Language:

english

File:

PDF, 650 KB

english, 1996

43

Corrigendum to “Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for ‘polymerisation’”: [Carbohydrate Research 317 (1999) 63–84]

Philippe Duchaussoy, Guy Jaurand, Pierre-A. Driguez, Isidore Lederman, Françoise Gourvenec, Jean-M. Strassel, Philippe Sizun, Maurice Petitou, Jean-M. Herbert

Journal:

Carbohydrate Research

Year:

2000

Language:

english

File:

PDF, 37 KB

english, 2000

44

Synthèse du 2-acétamido-2-désoxy-6-O-(α-D-glucopyranosyl)α-D-galactopyranose et de son p-aminophényl-α-glycoside

Maurice Petitou, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1975

File:

PDF, 676 KB

1975

45

Synthèses des p-nitrophényl- et p-aminophényl-2-acétamido-2-désoxy-β-D-galactopyranosides, à partir d'un composé ayant une configuration D-gluco

Maurice Petitou, Pierre Sinaÿ

Journal:

Carbohydrate Research

Year:

1973

File:

PDF, 482 KB

1973

46

Structural characterization of sulfated glycosaminoglycans by fast atom bombardment mass spectrometry: application to heparin fragments prepared by chemical synthesis

Vernon N. Reinhold, Steven A. Carr, Brian N. Green, Maurice Petitou, Jean Choay, Pierre Sinay

Journal:

Carbohydrate Research

Year:

1987

Language:

english

File:

PDF, 559 KB

english, 1987

47

Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(β-d-glucopyranosyluronic acid)-(1→4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-d-glucopyranosyl)-(1→4)-O-(2-O-sulfo-α-l-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-d-glucopyranose decasodium salt, a heparin fragment having high affinity for antithrombin III

Maurice Petitou, Philippe Duchaussoy, Isidore Lederman, Jean Choay, Pierre Sinaÿ, Jean-Claude Jacquinet, Giangiacomo Torri

Journal:

Carbohydrate Research

Year:

1986

Language:

english

File:

PDF, 1.11 MB

english, 1986

48

Synthesis of the basic disaccharide unit of heparin

Guy Jaurand, Christine Tabeur, Maurice Petitou

Journal:

Carbohydrate Research

Year:

1994

Language:

english

File:

PDF, 521 KB

english, 1994

49

Assessment through chemical synthesis of the size of the heparin sequence involved in thrombin inhibition

Philippe Duchaussoy, Guy Jaurand, Pierre-A. Driguez, Isidore Lederman, Marie-L. Ceccato, Françoise Gourvenec, Jean-M. Strassel, Philippe Sizun, Maurice Petitou, Jean-M. Herbert

Journal:

Carbohydrate Research

Year:

1999

Language:

english

File:

PDF, 233 KB

english, 1999

50

Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for ‘polymerisation’

Philippe Duchaussoy, Guy Jaurand, Pierre-A. Driguez, Isidore Lederman, Françoise Gourvenec, Jean-M. Strassel, Philippe Sizun, Maurice Petitou, Jean-M. Herbert

Journal:

Carbohydrate Research

Year:

1999

Language:

english

File:

PDF, 323 KB

english, 1999

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